In Vitro Hypoglycemic Activity of Aqueous and Methanolic Phyllanthus Odontadenius Extracts

Abstract

Diabetes mellitus, is one of the metabolic diseases responsible for main biotic stresses experienced by patients who suffer from it. Their devastating effects, due to oxidative stress from Reactive oxygen species, that are worsening daily and reaching undeniable epidemic proportions. Plants occupy a prominent place in human life since ancient times.  Treating diabetes success with plants or plant-derived products would be of great interest because modern medications are not only expensive but sometimes cause adverse effects. Among used medicinal plants to alleviate stress caused by various metabolic diseases, Phyllanthus odontadenius is also considered one of included plants. Given plant medicinal importance, we investigated whether extracts might contain beneficial secondary metabolites could be used in diabetes treatment. This is the rationale for this in vitro study, which aims to answer the question. P. odontadenius aqueous and methanolic extracts assessment in vitro hypoglucemic activity from three sites realized. Results obtained in this study show that these plants contain secondary metabolites such as flavonoids, alkaloids, anthocyanin’s and others compounds which could be explain also the P. odontadenius glucophagic effects. However, glucose inhibitory power effects on both P. odontadenius extracts, IC50 = 3.54±1.11 mg/ml for Kasangulu, 2.92±0.59 mg/ml for Kinshasa and 3.59±1.13 for Kwango respectively for aqueous extracts and IC50 = 3.37±0.67 mg/ml for Kasangulu, 3.10±0.32 for Kinshasa and 3.69±1.00 mg/ml for Kwango respectively for methanolic extracts, are less in comparison to acarbose which used as positive control (1.31±0.62 mg/ml for aqueous extract and 1.71±0.42 for methanolic extract). Following the obtained results, P. odontadenius plants contain secondary metabolites active against diabetes but, it would be desirable to supplement this work with in-depth research, particularly on in vivo *P. odontadenius*antidiabetic activity assessment.