Solid Variant of Papillary Thyroid Carcinoma in A 15-Year-Old Boy: Diagnostic Utility of Immunohistochemical Panel

Abstract

We present case of 15-year-old boy having solid-trabecular histological type in low-differentiated variant of PTC. The interest in the described case is also determined by the fact that in the preoperative examination of the patient thyroid nodular goiter and Hürthle cell adenoma of indefinite atypia by FNA (Bethesda III) was fixed, no PTC-induced changes and family history and radiation exposure was absent. In fact, we had three clinical-morphological versions: 1. Hürthle cell adenoma; 2. Nodular goiter; 3. PTC solid-trabecular variant. Differential diagnosis between medullary and anaplastic carcinomas should to be made by using of histological and immunohistochemical methods. A multicomponent immunohistochemical study have shown the high activity of TTF1, Cyclin D1 and thyroglobulin in combination with the activity of E-CAD indicating on the solid-trabecular variants of PTC, the epithelial phenotype and the transcription activity of thyroid-specific proteins were preserved, which is significant. Coordinated activity of TTF1 and Cyclin D1 is manifested by tumor tissue growth and differentiation and this phenomenon explains the tumor spread isolated characters and no local metastasis, which is one of highlight of our case. Therefore, the presented case does not have any features of undifferentiated carcinoma.