Evaluation of the Effect of Simvastatin, Atorvastatin, Rosuvastatin on Alcohol Induced Hypercholesterolemia in Female Wistar Rat

Abstract

 This study evaluated the effect of simvastatin, atorvastatin and rosuvastatin in alcohol induced hypercholesterolemia (HCM) in female Wistar rat.  Thirty (30) adults’ female Wistar rat with body weight 180-210g were divided into 5 groups of 6 rats each. Hypercholesterolemia (HCM) was induced in rats through oral administration of alcohol for 2 weeks. Group A was received water and feed only and served as the normal control, Group B was induced with HCM  without treatment, Group C,D and  were induced with HCM + 3.5mg/kg of Simvastatin, HCM + 3.5mg/kg of Atorvastatin, HCM + 3.5mg/kg of Rosuvastatin respectively. The findings of this study revealed that, the use of simvastatin, rosuvastatin and atorvastatin for 14 days did not prevent weight gain in rats, all of the statin used increased high density lipoprotein cholesterol  (HDL-C) levels, there was decrease in Triglyceride (TG) concentration by group E also a decrease in the low density lipoprotein cholesterol (LDL) levels in rosuvastatin .There was statistically significant difference (P<0.05) when compared with those of simvastatin group but there was no statistically  (P>0.05) significant difference compared with atorvastatin group .It observed that Statins (Simvastatin, Atorvastatin and Rosuvastatin) could prevent alcohol-induced hypercholesterolemia and its related effects. Therefore, the study recommended among others that Government could also fund public health campaigns that could raise awareness about the risks of alcohol-induced hypercholesterolemia in both human and animal modelled study.