Protective Effect of Zingiber Officinale Extract on Streptozotocin Induced Diabetes Mellitus in Mice

Abstract

Spices, the predominant flavoring, coloring, and aromatic agents in food and beverages are now gaining importance for their diversified uses. Ginger (Zingiber Officinale) is a medicinal plant that has been widely used in Chinese, and Tibb Unani herbal medicines all over the world, since antiquity, for a wide array of unrelated ailments that include muscular aches, sore throat, constipation, arthritis, indigestion, vomiting and infectious diseases. Currently, there is a renewed interest in ginger, and several scientific investigations aimed at isolation and identification of active constituents of ginger, scientific verification of its pharmacological actions and of its constituents, and verification of the basis of the use of ginger in several diseases and conditions most common is use of ginger as complementary therapy in diabetes patients is now increasing due to less side effect comparing with antidiabetic drugs. Streptozotocin enter the B cell via glucose transporter (GLUT2)  and cause alkylation of DNA. DNA damage induced by activation of poly ADP-ribosylation , a process is more important for diabetogenicity of streptpzotocin than DNA damage itself.