Metal Complexes of Schiff Base Derived from Ethylenediamine, Nitro and Chlorobenzaldehyde; Synthesis, Characterization, Biological and Toxicological Study

Abstract

Synthesis, characterization, antimicrobial and toxicology study of nikel(II), cobalt(II) and manganese (II) complexes with N, N-bidentate ligand derived from 4-nitrobenzaldehyde, 3-chlorobenzaldehyde and ethylenediamine are reported. The synthesized compounds, ligand(L): [C₁₆H₁₃ClN₃O₂] and metal complexes : [NiL(H₂O)₂]SO₄.3H₂O, [Co(L)₂Cl(H₂O)] Cl.4H₂O and [Mn(L)₂SO₄(H₂O)] were characterized by FTIR, G.C-Ms, UV-Vis, (¹H, ¹³C) NMR Spectra, elemental analysis, molar conductivity, and susceptibility measurement. The results of spectroscopic studies revealed that Schiff base ligand coordinated with metal ions through the (-C=N) nitrogen atoms in a bidentate form with the evidence of new bonds due to ν(M-N) vibration in metal complexes. The prepared compounds were screened against five bacteria; Staphylococcus aureus, Bascillus subtilis, Escherichia coli, Klebsiella pneumonia, shigella flexneri and two fungi; Candida albicans and Aspergillus fumigatus. The results revealed that both the ligand and its complexes possess good activity against the tested microorganisms. Toxicological results showed that the prepared compounds possess low toxicity level on selected liver function indices in wistar rats compared with the standard drug Amoxicillin.