Design of a Clinical Practice Guideline for the Prevention, Control, Diagnosis and Treatment of Fungemia in Adult Patients

Abstract

Introduction: Opportunistic fungal infections have become an important cause of morbidity and mortality in hospitalized patients. Most of the increase in these infections can be attributed to the increase in the use of new and more effective antibacterial agents, organ transplants, immunosuppressive and cytostatic therapies, the emergence of acquired immunodeficiency syndrome (AIDS) and the emergence of strains resistant to different antifungals. Most infections are attributable to Candida, Trichosporon, Rhodotorula, Cryptococcus, and Geotrichum. Justification: Through the construction of this guide, it is expected that the prevention, control, diagnosis and treatment of fungal infections in adult patients will have a positive impact on the control of risk factors, the more rational and cost-effective use of tools of the laboratory and antifungals. It lays the foundations for the creation of an active fungemia surveillance system in the country. Scientific problem: Increased morbidity and mortality of hospitalized adults as a result of invasive fungal infections. Aim: Design, develop, disseminate, implement and evaluate a Clinical Practice Guide applied to patients with suspected Fungemia to standardize prevention, control, diagnosis and appropriate treatment. The main result will be the design of a Clinical Practice Guide for the prevention, control, diagnosis and treatment of fungemia in adult patients which will offer recommendations based on the best evidence to reduce the variability in the diagnosis and treatment of this condition, reducing the complications of it.